Where Biology Leads and Cells Guide the Way

Cells are nature’s most powerful sensors. Soley captures the information sensed by living human cells and their response to stress in real time, creating a complete view of cell fate decisions that guide our drug discovery and development.

How Cells Decide Their Fate

What a cell senses, and for how long, shapes its fate: death, survival, proliferation, quiescence (or hibernation/dormancy), senescence, and/or differentiation. Stressors, such as a small molecule drug, can lead to different fates across cell types and disease stages.

What We Mean by “Cellular Sensing”

Cells continuously sense their environment and route information through dynamic protein movement, expression, and localization, affecting organelle function, membrane dynamics, and many other features. We record these changes in live cells, under disease or drug exposure, and convert image features into structured readouts with proprietary computer vision and AI, so our scientists can distinguish selective drug activity from toxicity and generate mechanism of action and pathways to discover new medicines.

How the Soley Platform Works

From Whole Cell Behavior to Selective Medicines

We start from cell-sensing that dictates whole-cell behavior. This is different than starting with a preselected target. We uncover the targets and delineate the mechanism of action of a drug once we see a desirable map of what the cell is sensing using our proprietary approaches.

Cell Sensing at Scale

We put diverse human cell types in conversation with thousands of compounds to understand what the cell is sensing by recording time-resolved cellular features of real signaling and stress responses. Computer vision discerns features, unseeable to the human eye, that are consequences of multitude of intracellular events such as protein movement, localization, expression, organelle and membrane dynamics, and many more.

SoleyMap™: From Molecule to Mechanism

We convert image-based whole cell-derived information into a structured text format. Each molecule yields a compact response signature, called a SoleyMap™, that captures what a cell senses and how it responds to a given drug. AI models read these signatures to compare compounds and conditions, separate selective therapeutics from toxic collapse, and articulate mechanisms and pathways of action using Soley’s proprietary and powerful SoleyMap™ Data Warehouse.

Cell State Gives Clinical Insight

We match mechanisms to disease biology, select indications, and define responder subgroups. Cell-state readouts inform dose and treatment schedules and highlight potential liabilities early so clinical studies can be designed with confidence. AI accelerates what the cells already tell us; it does not replace experiments.

AI to Amplify Biology + Automation to Accelerate

Imaging AI extracts cell sensing features and converts them into structured data; language models compare response patterns to surface mechanistic cues; chemistry models forecast hits and guide design; and Quality Control models detect plate effects and drift. A first-in-class, fully automated, in-house infrastructure enables screening of 100,000+ compounds per week, with compound handling, imaging, and analysis engineered for reliability, efficiency, robustness, and scalability. A novel data analysis workflow ensures consistent, biology-grounded decisions across cells and conditions.

Two Paths, One Platform

Modulating Cellular Stress as a Selective Therapeutic Force

Selective Stress Induction: Oncology

We identify compounds that selectively intensify stress signals within cancer cells with survival wiring, pushing them toward death and filtering out broadly toxic molecules early allowing broad therapeutic index against non-cancer cells

Stress Reversal: Non-oncology

In diseases marked by cellular exhaustion or stress dysregulation, we find therapeutic compounds and mechanisms that restore healthier cell states resilience.